Hello Shin.

Congratulations, once again, on your excellent article. As usual, you clarify complex issues supported by sound scientific literature. And expert opinion too. Your undoubted expertise gets transforming the information into a clear and understandable matter.

On your last contribution, an article still pre-print can be a good complement. Dugan et al.* analyze the response of memory B cells in natural infection in 38 patients.

The authors stress the idea of original antigen sin. They write: "...the early response to SARS-CoV-2 in some patients may be dominated by an original antigen sin response, as plasmablasts are often reactivated from pre-existing memory."

Best regards and thanks.

A.

(*) Profiling B cell immunodominance after SARS-CoV-2 infection reveals antibody evolution to non-neutralizing viral targets (DOI: https://doi.org/10.1016/j.immuni.2021.05.001).