No evil lasts a hundred years.

On the current pandemic, saturation affects the general population and front-line health care providers. There is a fed-up among people about SARS-CoV-2 and its many circumstances: political, economic, media, and health. All we need is breath!

It is not prudent playing to be or pretending to guess the future as a vulgar XXI Century’s seer. SARS CoV-2 has demonstrated an unquestionable capacity to surprise. From its natural origin to the ways of contagion.


The death of Don Quixote, by Gustave Doré (1832–1883). Image: WikiArt.org.

‘Señores’ ―said Don Quixote― no so fast because in the nests of yesteryear there are no birds this year.

Don Quixote (Chap. LXXIV)


A man with “fake news” rushing to the printing press. Extract of “The fin de siècle newspaper proprietor”. Wikimedia Commons

In the history of medicine, some issues caused great controversy when they surged. It usually occurs in science in general. Time is a great sculptor of life’s avatars. It usually resolves the conflicts, but, occasionally, some disputes are perennial. An excellent example of a non-resolved argument is Syphilis’s geographical origin. In synthesis: there are two great groups of opinions, with a third more undefined and diverse.

We will focus our brief analysis on two antagonistic positions because of a question of limited space. …


The writing process is not always a creative art.

I want to vindicate a forgotten and excellent writer: Heinrich von Kleist.

Heinrich von Kleist, by Peter Friedel, 1801. Image: Bildindex

Literature, like life, is unjust and cruel on many occasions. When I speak of literature, I am referring to the creative art of oral or written expression. I compare literature to life because, according to John, the evangelist, the origin of everything, or the beginning of all things, was the Verb (John 1: 1–3). That is to say, the word (Of course, it is a simplification of the biblical meaning’s analysis).

Once upon a time, when human beings’ communication began, literature surged through the spoken word, not throughout…


Mutations are like identity cards of many viruses.

Viruses do not mutate because they want to do it.

It is a random phenomenon of nature.

Life’s avatars live in a combination fortuitous of four letters. They are Adenine (A), Guanine (G), Cytosine ©, Thymine (T) in the DNA, and A, G, C, and Uracil (U) in the RNA. In the DNA, there is T and U in the RNA.

A virus is, as someone said, an enigma enclosed in a layer of lipids. There are thousands of species of viruses, some formed by DNA and others by RNA. …


A warning for dilettantes.

When the devil has nothing to do, he plays at combining mutations in the coronavirus genome.

(Diabolic saying anonymous).

Credit image: Gordon Johnson (Pixabay)

SARS-CoV-2 pandemic causing COVID-19 appeared on the public scene in December 2020. The virus was already carrying mutations. It is a rule followed by its genome of almost 30,000 letters. A matter of chance. More viruses, the greater the chance of mutating.

According to the WHO, the coronavirus zoonotic origin is in some species of horseshoe bat ( spp.). It is unknown whether the coronavirus passed later through some animal intermediary. …


Hello Shin.

Congratulations, once again, on your excellent article. As usual, you clarify complex issues supported by sound scientific literature. And expert opinion too. Your undoubted expertise gets transforming the information into a clear and understandable matter.

On your last contribution, an article still pre-print can be a good complement. Dugan et al.* analyze the response of memory B cells in natural infection in 38 patients.

The authors stress the idea of original antigen sin. They write: "...the early response to SARS-CoV-2 in some patients may be dominated by an original antigen sin response, as plasmablasts are often reactivated from pre-existing memory."

Best regards and thanks.

A.

(*) Profiling B cell immunodominance after SARS-CoV-2 infection reveals antibody evolution to non-neutralizing viral targets (DOI: https://doi.org/10.1016/j.immuni.2021.05.001).


Pandemics used to be the consequence of several events’ conjunction.

Jules Henri Poincaré (1854–1912) was an intellectual whose wisdom encompassed diverse subjects. An authentic polymath. He made significant contributions to the mathematical sciences.

On his three-body problem solution, Albert Einstein (1879–1955) based the relativity theory. The cited three-body problem is a complex issue on stars’ mobility in the solar system. Poincaré laid the foundations of chaotic systems.

Nothing depends on chance, and nothing is random. There are specific laws that explain the fortuitous processes. Chance is only the measure of our ignorance, Poincaré wrote in his book .

Let say something about chaos and butterflies.

(


Pandemics used to be the consequence of several events’ conjunction.

Jules Henri Poincaré (1854–1912) was an intellectual whose wisdom encompassed diverse subjects. An authentic polymath. He made significant contributions to the mathematical sciences.

On his three-body problem solution, Albert Einstein (1879–1955) based the relativity theory. The cited three-body problem is a complex issue on stars’ mobility in the solar system. Poincaré laid the foundations of chaotic systems.

Nothing depends on chance, and nothing is random. There are specific laws that explain the fortuitous processes. Chance is only the measure of our ignorance, Poincaré wrote in his book .

Let say something about chaos and butterflies.

(


But, if you look at the Moon, do not forget from where the finger points.

The finger and the Moon. Credit: Xaverian Missionaries in Sierra Leone Web.

The problems of the poor people also affect the rich. Economies, countries, persons are three legs of a single bench. But what is being poor? Who is an economically poor person?

Let go to define it. It is a personal definition, of course. Nor academic, neither linguistic.

─A poor’s definition according to the economy: It is a person with no money nor goods.

─A poor’s definition according to social justice: It is a person without rights.

─A poor’s definition according to both disciplines: It is an injustice and immorality. It is a human and social tragedy.

Why write now about these things if I am still not vaccinated.

Coronavirus pandemic is an…

Agustín Muñoz-Sanz

Medical Doctor (Infectious Diseases specialist/Professor of Medicine) and writer (narrative, theater).

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